Difficulty in Intestinal Transplant
The intestine has been more difficult to transplant than other solid organs and some of the possible reasons include:
• the large number of white cells in the bowel provides a strong stimulus for rejection
• the large number of bacteria in the gut increases the risk of infection after transplantation
Patients must take anti-rejection drugs to suppress their immune system so their body will accept the transplanted bowel. They must take enough drugs to prevent rejection, but not too many or they may have problems with infection and drug toxicity. Prograf® (FK506, tacrolimus) is the most common anti-rejection drug used in intestinal transplantations.